• The FIAlab SIChrom is the first commercial Liquid Chromatography (LC) instrument based on the concept of Sequential Injection (SI). It combines the powerful sample processing capabilities of SI with the separation power of LC, thus offering a flow analyzer with unparalleled versatility.

    The chief advantage that SIChrom holds over other LC devices is the ability to carry out automated sample pretreatment prior to separation and analysis. When equipped with suitable accessories, it can implement any of the pretreatment operations that our other SI instruments are capable of:

    • chemical derivatization
    • Dilution
    • Heating
    • Solid phase extraction
    • Dialysis
    • Gas diffusion

    The chief advantage that SIChrom holds over other fluidic devices and analyzers is the ability to operate at elevated pressure. While most SI instruments are designed to handle max 50-100 psi back pressure, the SIChrom can tolerate over ten times that. When equipped with the standard 5 mL syringe, it can withstand 1,500 psi. With a 2.5 mL syringe, the upper pressure limit reaches all the way to 3,000 psi.

  • The SIChrom fluidic architecture consists of:

    • A bidirectional syringe pump, (rated to 1,500 psi back pressure with a 5 mL syringe)
    • Two selector valves (rated to 5,000 psi back pressure)
    • One injection valve (rated to 5,000 psi back pressure)

    As all of FIAlab's analyzers, the SIChrom can be equipped with a detector (UV-VIS absorbance or fluorescence). The separation protocols and data collection are controlled by the SIAsoft software.

    The most typical separation media used on the SIChrom are monolithic (e.g. Phenomenex Onyx™ or VWR Chromolith™) columns and core-shell (e.g. Sigma-Aldrich Ascentis Express™) columns.

    Contact FIAlab to find out more about this unique solution for fluidics at elevated pressure.

Product Highlights

Minimal Reagent Waste

Don’t waste precious reagents. Don’t generate unnecessary waste. SIA can operate with miniscule volumes that will save you money and hassle.

Add-on Components

Need to speed up your reaction? Add a heater. Need a chiller to cool your enzymatic reagents? Add a chiller. You can easily add components like these and others to any FIAlab instrument.

Operate Under Pressure

If you are performing chemical analysis at very pressures, the SIChrom is the instrument for you. Comfortably, reach pressures up to 3,000 psi.

On-line Applications

Our SIA instruments, paired with SIAsoft, provide unique, cutting-edge solutions for on-line monitoring and process analytical technology (PAT). These solutions are used in research facilities, quality control labs, and manufacturing plants.

Software

Sequential injection analysis is an intricate, dynamic analysis technique. The sheer number of actions, flow paths, and valves requires powerful computer control. As a result, we created SIAsoft. This new software packs a plethora of useful functions into a user-friendly interface. You can even use Python Scripting to build custom methods. Click below to find out more.

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